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JohnCMarch @ lifesciences.cornell.edu
| Description | : | "Our gastrointestinal tracts contain a variety of commensal bacteria that digest our food, kill harmful microorganisms, and help us function.
Investigators are beginning to engineer such bacteria to make them even more beneficial. Duan and March have augmented a signaling pathway that enables a model probiotic bacterium, Escherichia coli Nissle 1917 (Nissle), to ward off cholera. The pathogenic bacterium Vibrio cholerae contains a signaling pathway that is sensitive to secreted autoinducers whose environmental concentration increases as the population density increases... Although much further work needs to be done, the authors speculate that this might be an important preventive approach in regions where natural disaster increases the probability of an outbreak or even as part of the diet in impoverished areas" www.pnas.org/content/107/25/11260 |
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